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A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Acetyl dipeptide-1 cetyl ester

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Calmosensine, acetyl tyrosylarginine cetyl ester, Sensicalmine, Ac-Tyr-Arg-cetyl ester, Hexadecyl acetyl-L-tyrosyl-L-argininate, N-Acetyl dipeptide-1 cetyl ester, N-Acetyl-Tyrosyl-Arginyl-Hexadecyl Ester

Evidence score
23/ 100
Thin evidence

Very thin human evidence

  • Regulatory standing. Cosmetic ingredient, not regulated as a drug
  • Animal / preclinical only. Evidence is largely animal or in-vitro
  • No registered human trials. Nothing registered on ClinicalTrials.gov
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Acetyl dipeptide-1 cetyl ester, sold under the trade name Calmosensine, is a small synthetic peptide used as an ingredient in skin care products. It is a modified dipeptide (tyrosine-arginine) with an attached fatty cetyl group to help it penetrate skin, and it is thought to act on skin nerve signaling pathways related to comfort and sensitivity.

What the evidence shows

Automatic summaryAnimal / preclinical

It is regulated as a cosmetic ingredient, is not FDA-approved for any medical use, and has no registered human clinical trials. Evidence consists of a small number of published papers and manufacturer testing, so claimed soothing or skin comfort effects are not well established in independent human research.

Key facts

Molecular formula
C33H57N5O5
Molecular weight
603.8 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies
Nonemost advanced phase
0completed (sample)
0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

5papers referencing Acetyl dipeptide-1 cetyl ester

Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A.

J Eur Acad Dermatol Venereol2016

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Pharmaceuticals (Basel)2021

Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin.

J Eur Acad Dermatol Venereol2016

A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.

J Cosmet Dermatol2020

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.