Afamelanotide (Melanotan I)
FDA APPROVED · RXMelanocortin receptor agonist
Also known as: Scenesse, Melanotan I, NDP-MSH
FDA approved and prescription only. Sold as Scenesse to reduce phototoxicity in erythropoietic protoporphyria (EPP), a rare light-sensitivity disorder.
A real evidence base, with gaps
- Regulatory standing. FDA-approved prescription medicine
- Human trials. Backed by controlled human studies
- No registered human trials. Nothing registered on ClinicalTrials.gov
- 1 cited source. Cited references provided
A read on the weight of evidence and regulatory standing behind this compound. It is not a safety score, not a purity or quality rating, and not medical advice. It is not a claim that this compound treats, cures, or prevents any condition, and not an endorsement or a recommendation to buy or use it. A low score means the evidence is thin — not that a product is unsafe; a high score means the evidence is strong — not that anyone should take it. PLOBT is independent and takes no money from any vendor; no company can pay to change this score.
Proven in human trials: it increases pain-free light exposure in people with EPP, which is what it is approved for. It is NOT a consumer tanning product, and it is delivered as a prescribed implant, not gray-market vials.
What it is
A selective melanocortin-1 receptor agonist that increases eumelanin, providing photoprotection.
What the research says
Approved on human trial data for this rare disorder.
Registered human trials
Live from ClinicalTrials.gov, the US NIH registry of human studies, refreshed daily. Counts studies where Afamelanotide (Melanotan I) is the intervention being tested.
No interventional studies for Afamelanotide (Melanotan I) are registered on ClinicalTrials.gov. That is not proof it is unsafe or useless, but it means the human evidence here does not come from registered clinical trials, the exact gap the marketing tends to hide.
FDA recalls & enforcement
No FDA recalls are on record for Afamelanotide (Melanotan I).
Source: openFDA drug enforcement.
What people log it for
Descriptive, based on what users track. Not an endorsement or a suggested use.
Risks & unknowns
- Approved for a specific rare disease, not general tanning.
- Administered and monitored by a clinician.
Doses reported in studies & protocols
Delivered as a clinician-placed implant per the label. This is not a recommendation.
Purity reality
Prescription implant with a verified supply chain.
None yet. PLOBT does not publish invented purity numbers. Real third-party COA data, mapped to vendor and batch, is in development — and it is the one thing we refuse to fake.
Sources
We cite peer-reviewed journals, PubMed/PMC, FDA and university sources, not vendor marketing.