Sold as a supplement, not an FDA-approved drug. This page is educational information only, not medical advice.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Anserine

Supplement

Histidine-containing dipeptide

Also known as: L-Anserine, beta-alanyl-3-methyl-L-histidine, L-Histidine, N-beta-alanyl-3-methyl-, Balanine, Beta Alanyl 3 Methylhistidine, Beta-Alanyl-3-Methylhistidine

Evidence score

53/ 100

Moderate evidence

A real evidence base, with gaps

Regulatory standing. Sold as a supplement, not an approved drug
Limited human data. Some human data exists, not conclusive
Registered human trials. 14 registered studies on ClinicalTrials.gov, most advanced Phase 2
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Anserine is a naturally occurring dipeptide made of beta-alanine and methylated histidine, found mainly in the muscle of poultry and fish. It is closely related to carnosine and is sold as a dietary supplement, often combined with carnosine from chicken extract. It is thought to act as an antioxidant, pH buffer, and metal chelator in tissues.

What the evidence shows

Automatic summaryLimited human data

There are registered human trials (up to Phase 2) and some small studies looking at areas such as cognition, fatigue, and uric acid, but results are preliminary and not conclusive. It is not FDA-approved for any condition, and no benefit is established in humans.

Key facts

Molecular formula

C10H16N4O3

Molecular weight

240.26 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

14registered studies

Phase 2most advanced phase

7completed (sample)

0recruiting (sample)

Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients

CompletedNCT07881913

Efficacy of Neural Prolotherapy for Treatment of Anserine Bursitis "NPCAB"

CompletedNCT04509440

Efficacy of Corticosteroid and Local Anesthetic Injections Patients With Concomitant Pes Anserine Bursitis

CompletedNCT04887844

A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product.

Phase 2UnknownNCT00208000

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

1,011papers referencing Anserine

Physiology and pathophysiology of carnosine.

Physiol Rev2013

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.

Proc Natl Acad Sci U S A1988

Free amino acids and peptides as related to antioxidant properties in protein hydrolysates of mackerel (Scomber austriasicus)

Food Res Int2003

The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis.

Amino Acids2006

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.