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A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Biotinoyl tripeptide-1

Cosmetic ingredient

Cosmetic biotinylated peptide

Also known as: Procapil, biotinoyl-GHK, Biotin-GHK, Biotin Tripeptide-1(acetate), Bio-GHK, Biotinoyl GHK, Biotinoyl-Tripeptide-1, BiotinoylTripeptide-1?

Evidence score
41/ 100
Emerging evidence

Early evidence, mostly unproven in humans

  • Regulatory standing. Cosmetic ingredient, not regulated as a drug
  • Limited human data. Some human data exists, not conclusive
  • Registered human trials. 2 registered studies on ClinicalTrials.gov
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Biotinoyl tripeptide-1 is a lab-made peptide in which biotin is attached to the tripeptide glycine-histidine-lysine (GHK). It is used as a cosmetic ingredient in hair and scalp products, sometimes as part of the blend marketed as Procapil. It is thought to act on hair follicle cells by supporting anchoring of the hair to the follicle, but this mechanism comes mainly from manufacturer and lab data.

What the evidence shows

Automatic summaryLimited human data

It is not FDA-approved and is sold only as a cosmetic ingredient. Two registered human trials exist with no listed phase and no indexed published papers, so any effect on hair loss in people is not established.

Key facts

Molecular formula
C24H38N8O6S
Molecular weight
566.7 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

2registered studies
Nonemost advanced phase
2completed (sample)
0recruiting (sample)

Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study

CompletedNCT06875687

A Single-Group Study to Evaluate the Effects of an Eyelash Serum on Improving Eyelash Growth

CompletedNCT06125730

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.