Calcitonin salmon
FDA approved · RxCalcitonin hormone analog
Also known as: Miacalcin, calcitonin, Salmon calcitonin, CALCITONIN, SALMON, Salcatonin, Calcitonin-salmon, Calcimar, Tonocalcin, Calcitonin,salmon, Forcaltonin
Strong, human-grade evidence
- Regulatory standing. FDA-approved prescription medicine
- Human trials. Backed by controlled human studies
- Registered human trials. 154 registered studies on ClinicalTrials.gov, most advanced Phase 4
- 2 cited sources. Includes primary / regulatory sources
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Calcitonin salmon is a synthetic version of the 32 amino acid hormone calcitonin originally found in salmon, which is more potent in humans than human calcitonin. It binds calcitonin receptors on osteoclasts, the cells that break down bone, reducing bone resorption and lowering blood calcium levels.
What the evidence shows
It is FDA approved for Paget's disease of bone, hypercalcemia, and postmenopausal osteoporosis (the osteoporosis indication generally in women for whom other treatments are not suitable), with a long record of human trials through Phase 4. Its effect on reducing fractures is considered modest compared with newer osteoporosis drugs, and regulators have noted a possible small increase in cancer risk with long-term use.
Key facts
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)
A Study of Oral Calcitonin Given at Night to Healthy Postmenopausal Women
Comparing Efficacy and Safety of 2 Dose Regimens of Subcutaneous Administration of TEV-48125 Versus Placebo for the Preventive Treatment of Chronic Migraine
Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
High affinity amylin binding sites in rat brain.
Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development.
Central nervous system actions of calcitonin gene-related peptide on gastric acid secretion in the rat.
Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.
Sources
- PubChem compound record (CID 16220016)
- FDA drug label on DailyMed
- Registered trials on ClinicalTrials.gov
- Published papers on Europe PMC
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.