Casein hydrolysate
SupplementMilk protein hydrolysate
Also known as: Lactium, casein peptides
Early evidence, mostly unproven in humans
- Regulatory standing. Sold as a supplement, not an approved drug
- Limited human data. Some human data exists, not conclusive
- Registered human trials. 8 registered studies on ClinicalTrials.gov, most advanced Phase 4
- No sources. Nothing cited to verify
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Casein hydrolysate is a mixture of peptides made by enzymatically breaking down casein, the main protein in cow's milk. It is sold as a dietary supplement, with branded forms such as Lactium marketed for relaxation and sleep, and other forms used in infant formulas and sports nutrition. Some of its peptides, such as alpha-casozepine, are thought to interact with GABA-A receptors, and others are studied for effects on blood pressure or muscle protein synthesis.
What the evidence shows
There are some small human trials, about 8 registered, on stress, sleep, blood pressure, and nutrition, but results are mixed and not conclusive for any specific health benefit. It is not FDA-approved as a drug, and its effects as a supplement remain uncertain.
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Step Down Approach in Children With Cow Milk Allergy
Research on Sleep and Emotion Testing of Tea Theanine Casein Hydrolysate Pressed Candy
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Alpha-s1 Casein Hydrolysate on Sleep
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men.
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance.
Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790.
Sources
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.