Cosyntropin
FDA approved · RxSynthetic ACTH analogue
Also known as: Cortrosyn, tetracosactide, Tetracosactide, Tetracosapeptide, Tetracosactid, Actholain, Synacthen, Tetracosactrin
Strong, human-grade evidence
- Regulatory standing. FDA-approved prescription medicine
- Human trials. Backed by controlled human studies
- Registered human trials. 42 registered studies on ClinicalTrials.gov, most advanced Phase 4
- 2 cited sources. Includes primary / regulatory sources
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Cosyntropin, also called tetracosactide and sold as Cortrosyn, is a synthetic peptide made of the first 24 amino acids of human adrenocorticotropic hormone (ACTH). It binds ACTH receptors on the adrenal cortex and stimulates the release of cortisol, which lets clinicians see how well the adrenal glands respond.
What the evidence shows
Cosyntropin is FDA approved for use as a diagnostic agent in testing adrenocortical function, such as the ACTH stimulation test for suspected adrenal insufficiency. Its diagnostic role is well established, supported by 41 registered human trials reaching Phase 4 and over 700 published papers, while uses outside diagnostic testing are not established in the US.
Key facts
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury
Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Hormonal Mechanisms of Sleep Restriction - Axis Study
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
Measurements of serum free cortisol in critically ill patients.
Congenital adrenal hyperplasia.
The Adrenal Vein Sampling International Study (AVIS) for identifying the major subtypes of primary aldosteronism.
Diagnosis of adrenal insufficiency.
Sources
- PubChem compound record (CID 16129617)
- FDA drug label on DailyMed
- Registered trials on ClinicalTrials.gov
- Published papers on Europe PMC
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.