Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Dihexa

Not FDA approved

Angiotensin IV analog

Also known as: PNB-0408, ATH-1001, Hexanoyl-Tyr-Ile-Ahx-NH2, Dihexa (PNB-0408)?, orb1220467, orb1685499

Evidence score

21/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Sold as a research chemical, not approved
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Dihexa (PNB-0408) is a small synthetic peptide-like compound derived from angiotensin IV, developed in academic research on memory and brain function. It is thought to act by enhancing hepatocyte growth factor (HGF) signaling through its c-Met receptor, which may support the formation of new connections between nerve cells.

What the evidence shows

Automatic summaryAnimal / preclinical

There are no registered human trials, and the published work (about 18 papers) is mainly animal and laboratory research, including rodent studies of learning and memory. Its effects, safety, and long-term risks in humans are not established, and it is not approved for any use.

Key facts

Molecular formula

C27H44N4O5

Molecular weight

504.7 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

18papers referencing Dihexa

Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers.

Molecules2014

Localization of alveolar surfactant clearance in rabbit lung cells.

Am J Physiol1992

Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.

Neurosci Biobehav Rev2018

Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.

J Pharmacol Exp Ther2013

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.