Gonadorelin
FDA approved · RxSynthetic GnRH analog
Also known as: Factrel, GnRH, Gonadorelina, GnRH-I, Gonadorelinum, Fertagyl, LH-Releasing factor, Luforan, Lutrefact
Strong, human-grade evidence
- Regulatory standing. FDA-approved prescription medicine
- Human trials. Backed by controlled human studies
- Registered human trials. 1164 registered studies on ClinicalTrials.gov, most advanced Phase 4
- 1 cited source. Includes primary / regulatory sources
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH), a 10-amino-acid peptide made by the hypothalamus. It acts on the pituitary gland to trigger release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn regulate the testes and ovaries.
What the evidence shows
Under the brand Factrel, gonadorelin was approved for diagnostic testing of pituitary gonadotropin function, but current FDA marketing status could not be confirmed and the branded product appears to be discontinued in the US. Its hormonal effects on LH and FSH are well documented in humans, while off-label uses promoted in community settings have little direct supporting evidence, and the large trial count likely includes broader GnRH research.
Key facts
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease
the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer .
Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.
LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin and buserelin.
Preparation and characterization of solid lipid nanoparticles containing peptide.
Low progesterone concentration during the development of the first follicular wave reduces pregnancy per insemination of lactating dairy cows.
Sources
- PubChem compound record (CID 638793)
- Registered trials on ClinicalTrials.gov
- Published papers on Europe PMC
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