← Library
A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Hexapeptide-10

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Serilesine, H-Ser-ile-lys-val-ala-val-OH, SIKVAV (acetate), Hexapeptide-10?, Hexapeptide-10 (Silitide), orb1907328

Evidence score
23/ 100
Thin evidence

Very thin human evidence

  • Regulatory standing. Cosmetic ingredient, not regulated as a drug
  • Animal / preclinical only. Evidence is largely animal or in-vitro
  • No registered human trials. Nothing registered on ClinicalTrials.gov
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Hexapeptide-10, sold under the trade name Serilesine, is a short synthetic peptide used as an ingredient in skin care products. It is described by suppliers as a signal peptide that may support skin cell adhesion and the structure of the layer between the outer and inner skin, based mainly on laboratory work.

What the evidence shows

Automatic summaryAnimal / preclinical

It is regulated as a cosmetic ingredient, not a drug, and has no registered human clinical trials and only about two published papers. Claims about firmness or anti-aging effects rest largely on manufacturer and lab data, so benefits in people are not established.

Key facts

Molecular formula
C28H53N7O8
Molecular weight
615.8 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies
Nonemost advanced phase
0completed (sample)
0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

2papers referencing Hexapeptide-10

Drinking and haemodynamic changes induced in the dog by intracranial injection of components of the renin-angiotensin system.

J Physiol1978

Phosphite-Mediated Peptide Bond Formation through Fragment Condensation.

J Org Chem2026

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.