A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Hexapeptide-11

Cosmetic ingredient

Cosmetic signaling peptide

Also known as: Peptamide 6, Fvapfp, Phe-val-ala-pro-phe-pro, orb1983751, TP2341, AT41883

Evidence score

23/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Cosmetic ingredient, not regulated as a drug
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Hexapeptide-11 is a short synthetic peptide made of six amino acids, used as an ingredient in skin care products. It is thought to act as a signaling molecule in skin cells, with lab studies suggesting it may influence genes related to cellular aging, stress responses, and the extracellular matrix.

What the evidence shows

Automatic summaryAnimal / preclinical

There are no registered human clinical trials, and the small published literature of about eight papers consists mostly of cell culture and laboratory work. Any effects on human skin are not established.

Key facts

Molecular formula

C36H48N6O7

Molecular weight

676.8 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

8papers referencing Hexapeptide-11

Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.

Redox Biol2015

Designing topical hyaluronic acid technology-Size does matter….

J Cosmet Dermatol2022

Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts.

Skin Pharmacol Physiol2021

Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro.

J Cosmet Sci2013

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.