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A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Hexapeptide-9

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Collaxyl, Apepbiosix-5, Gly-Pro-Gln-Gly-Pro-Gln, Hexapeptide 9, Hexapeptide-9 (acetate), Collaxyl IS, Hexapeptide-9?

Evidence score
23/ 100
Thin evidence

Very thin human evidence

  • Regulatory standing. Cosmetic ingredient, not regulated as a drug
  • Animal / preclinical only. Evidence is largely animal or in-vitro
  • No registered human trials. Nothing registered on ClinicalTrials.gov
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Hexapeptide-9, sold under the trade name Collaxyl, is a short synthetic peptide used as an ingredient in cosmetic skin care products. Its sequence is modeled on fragments of collagen, and it is thought to act as a signaling peptide that may encourage skin cells to produce structural proteins such as collagen. It is regulated as a cosmetic ingredient, not as a drug.

What the evidence shows

Automatic summaryAnimal / preclinical

There are no registered human clinical trials and only a small number of published papers, with most support coming from lab studies and manufacturer-reported data. Any effect on skin appearance in humans has not been established by independent, rigorous research.

Key facts

Molecular formula
C24H38N8O9
Molecular weight
582.6 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies
Nonemost advanced phase
0completed (sample)
0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

4papers referencing Hexapeptide-9

Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle.

J Biol Chem2007

Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.

J Cosmet Dermatol2025

A framework for the safety evaluation of peptides in cosmetics.

Curr Res Toxicol2026

Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions.

Mater Today Bio2025

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.