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Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Humanin

Not FDA approved

Mitochondrial-derived peptide

Also known as: HUMANIN TRIFLUOROACETATE, formyl humanin, Protein Humanin (human), Humanin, human, 1-24-Protein humanin (human), 1-24-Protein humanin

Evidence score
30/ 100
Emerging evidence

Early evidence, mostly unproven in humans

  • Regulatory standing. Sold as a research chemical, not approved
  • Animal / preclinical only. Evidence is largely animal or in-vitro
  • Registered human trials. 3 registered studies on ClinicalTrials.gov
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Humanin is a small peptide of about 24 amino acids encoded within mitochondrial DNA, first identified in studies of cells resistant to Alzheimer's-related damage. It is thought to act as a cell-protective signal, interacting with cell surface receptors and proteins involved in programmed cell death and stress responses. Researchers study it in the context of aging, neurodegeneration, and metabolism.

What the evidence shows

Automatic summaryAnimal / preclinical

Most evidence for protective effects comes from cell and animal studies; in humans, research has mainly measured natural circulating humanin levels in relation to age or disease rather than testing it as a treatment. It is not FDA-approved, and the few registered human trials have no clearly reported advanced phase, so benefits in people are unestablished.

Key facts

Molecular formula
C119H204N34O32S2
Molecular weight
2687.2 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

3registered studies
Nonemost advanced phase
1completed (sample)
1recruiting (sample)

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation

RecruitingNCT07678073

Clinical Value of Plasma Humanin in Acute Kidney Injury

UnknownNCT06105229

Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac Operation

CompletedNCT03431844

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

590papers referencing Humanin

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Cell Metab2015

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

Proc Natl Acad Sci U S A2001

Humanin peptide suppresses apoptosis by interfering with Bax activation.

Nature2003

Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.

Cytokine Growth Factor Rev2006

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.