Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

IGF-1 DES

Not FDA approved

Truncated IGF-1 analog

Also known as: DES(1-3) IGF-1

Evidence score

14/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Sold as a research chemical, not approved
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
No sources. Nothing cited to verify

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

IGF-1 DES, also called DES(1-3) IGF-1, is a shortened form of insulin-like growth factor 1 that lacks the first three amino acids. This change is thought to reduce binding to IGF binding proteins, which in lab studies makes it act more potently and locally at the IGF-1 receptor than full-length IGF-1.

What the evidence shows

Automatic summaryAnimal / preclinical

There are no registered human trials, and the small published literature (about six papers) is mostly laboratory and animal research. Effects in humans, including safety, are not established.

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

6papers referencing IGF-1 DES

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

Endocrinology1996

The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins.

Endocrinology1991

A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide.

Biochem J1989

Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis.

Oncogene2008

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.