Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Kisspeptin-10

Not FDA approved

Reproductive neuropeptide fragment

Also known as: kisspeptin, metastin, Kisspeptin-10 (human), Human metastin 45-54, Human kisspeptin 10F, Kisspeptin-10, human, KP-10, Metastin 45-54

Evidence score

48/ 100

Emerging evidence

Early evidence, mostly unproven in humans

Regulatory standing. Sold as a research chemical, not approved
Limited human data. Some human data exists, not conclusive
Registered human trials. 5 registered studies on ClinicalTrials.gov, most advanced Phase 3
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Kisspeptin-10 is a short 10 amino acid fragment of kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and originally named metastin. It activates the kisspeptin receptor (KISS1R, also called GPR54) in the brain, which triggers release of gonadotropin-releasing hormone and, downstream, luteinizing hormone and follicle-stimulating hormone.

What the evidence shows

Automatic summaryLimited human data

Human research studies, including a small number of registered trials, show that kisspeptin-10 can acutely raise reproductive hormone levels, and it is being studied as a research tool and for possible fertility-related uses. It is not FDA-approved for any indication, and evidence for lasting clinical benefit in humans remains limited and not conclusive.

Key facts

Molecular formula

C63H83N17O14

Molecular weight

1302.4 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

5registered studies

Phase 3most advanced phase

3completed (sample)

0recruiting (sample)

KP-10 and Insulin Secretion in Men

Phase 3CompletedNCT03771326

Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance

Phase 1WithdrawnNCT04532801

Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp

Phase 1WithdrawnNCT05456854

Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.

Phase 3CompletedNCT03286517

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

330papers referencing Kisspeptin-10

A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.

Endocrinology2004

Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.

J Neurosci2005

Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons.

Endocrinology2006

Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.

Proc Natl Acad Sci U S A2005

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.