Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

KPV

Not FDA approved

Alpha-MSH derived tripeptide

Also known as: Lys-Pro-Val, alpha-MSH fragment

Evidence score

14/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Sold as a research chemical, not approved
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
No sources. Nothing cited to verify

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

KPV is a short peptide made of three amino acids (lysine, proline, valine) that corresponds to the tail end of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for anti-inflammatory activity, which is thought to involve dampening inflammatory signaling such as the NF-kB pathway, possibly after uptake into cells through the PepT1 transporter in the gut.

What the evidence shows

Automatic summaryAnimal / preclinical

KPV is not approved for any use, and there are no registered human clinical trials. The published research, including work on models of inflammatory bowel disease and skin inflammation, is almost entirely from cell and animal studies, so its effects and safety in humans are not established.

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

119papers referencing KPV

Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.

Endocr Rev2008

Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.

Gastroenterology2010

New insights into the functions of alpha-MSH and related peptides in the immune system.

Ann N Y Acad Sci2003

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.

Mol Ther2017

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.