Lactotripeptides
SupplementMilk-derived bioactive tripeptides
Also known as: IPP, VPP, casein tripeptides
Very thin human evidence
- Regulatory standing. Sold as a supplement, not an approved drug
- Limited human data. Some human data exists, not conclusive
- No registered human trials. Nothing registered on ClinicalTrials.gov
- No sources. Nothing cited to verify
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Lactotripeptides are short peptides, mainly isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), produced when milk casein is fermented or enzymatically broken down. They are sold as dietary supplements and in some functional foods. They are thought to mildly inhibit angiotensin-converting enzyme (ACE), which plays a role in blood pressure regulation.
What the evidence shows
A number of small human studies and meta-analyses have looked at modest blood pressure effects, with mixed results that vary by population and study design, and no registered trials were found in the provided data. They are not FDA-approved for any condition, and any benefit remains uncertain.
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials.
Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials.
Antihypertensive Peptides from Milk Proteins.
Lactotripeptides show no effect on human blood pressure: results from a double-blind randomized controlled trial.
Sources
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.