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IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Macimorelin

FDA approved · Rx

Oral ghrelin receptor agonist

Also known as: Macrilen, AEZS-130, ARD-07, EP-1572, JMV-1843, EP1572, JMV 1843, macimorelina

Evidence score
84/ 100
Strong evidence

Strong, human-grade evidence

  • Regulatory standing. FDA-approved prescription medicine
  • Human trials. Backed by controlled human studies
  • Registered human trials. 6 registered studies on ClinicalTrials.gov, most advanced Phase 3
  • 2 cited sources. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Macimorelin is a small peptidomimetic compound, sold as Macrilen, that is taken by mouth and activates the ghrelin receptor (growth hormone secretagogue receptor). This stimulates the pituitary gland to release growth hormone, and the size of that response is measured in blood samples.

What the evidence shows

Automatic summaryHuman trials

Macimorelin is FDA approved for use as a diagnostic test for adult growth hormone deficiency, supported by Phase 3 trials among 6 registered human studies. It is not approved as a treatment for any condition, and evidence for other uses is not established.

Key facts

Molecular formula
C26H30N6O3
Molecular weight
474.6 g/mol
FDA approval
Confirmed on openFDA

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

6registered studies
Phase 3most advanced phase
6completed (sample)
0recruiting (sample)

Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency

Phase 3CompletedNCT02558829

Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers

CompletedNCT03844217

Investigation of a New, Oral Growth Hormone Secretagogue, AEZS-130 as a Growth Hormone Stimulation Test.

Phase 3CompletedNCT00448747

Oral Ghrelin Agonist in Healthy Subjects

Phase 1CompletedNCT00377377

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

38papers referencing Macimorelin

Generative Network Complex for the Automated Generation of Drug-like Molecules.

J Chem Inf Model2020

Macimorelin as a Diagnostic Test for Adult GH Deficiency.

J Clin Endocrinol Metab2018

Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency.

J Clin Endocrinol Metab2013

Current concepts of the diagnosis of adult growth hormone deficiency.

Rev Endocr Metab Disord2021

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.