Mechano growth factor
Not FDA approvedIGF-1 splice variant peptide
Also known as: MGF, IGF-1Ec
Very thin human evidence
- Regulatory standing. Sold as a research chemical, not approved
- Animal / preclinical only. Evidence is largely animal or in-vitro
- No registered human trials. Nothing registered on ClinicalTrials.gov
- No sources. Nothing cited to verify
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Mechano growth factor (MGF) is a splice variant of the insulin-like growth factor 1 gene, known in humans as IGF-1Ec, that is expressed in muscle and other tissues in response to mechanical load or damage. Its distinct C-terminal E-domain peptide is thought to activate muscle stem (satellite) cells and support local tissue repair, possibly through pathways partly separate from the main IGF-1 receptor.
What the evidence shows
Human research mainly measures natural MGF expression in muscle after exercise or injury. Evidence that synthetic MGF peptides produce benefits comes almost entirely from cell and animal studies. The registered trial count and Phase 4 listing likely reflect broader IGF-1 research rather than trials of MGF itself, and it is not approved for any use.
Sources
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.