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Not FDA approved and sold as a research chemical. This page is educational information only. It is not medical advice and not a recommendation to use anything.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

P21

Not FDA approved

CNTF-derived peptidomimetic

Also known as: P021, peptide 021

Evidence score
14/ 100
Thin evidence

Very thin human evidence

  • Regulatory standing. Sold as a research chemical, not approved
  • Animal / preclinical only. Evidence is largely animal or in-vitro
  • No registered human trials. Nothing registered on ClinicalTrials.gov
  • No sources. Nothing cited to verify

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

P21 (also called P021) is a small synthetic peptide derived from a fragment of ciliary neurotrophic factor (CNTF), modified to improve stability and brain penetration. It is thought to act by supporting neurotrophic signaling, such as increasing BDNF-related activity, and has been studied for effects on neurogenesis and memory.

What the evidence shows

Automatic summaryAnimal / preclinical

The published work on this peptide is almost entirely in rodent and cell models, including Alzheimer's disease models. The listed human trials and very large paper count likely reflect the unrelated p21 protein (CDKN1A) sharing the name, so it is unclear whether any human studies of this specific peptide exist, and no benefit in humans has been established.

This name is shared with unrelated compounds in public databases, so trial and paper counts are not shown here, and the evidence score counts no registered trials. Treat this profile as a starting point only.

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.