Palmitoyl oligopeptide
Cosmetic ingredientCosmetic signal peptide
Also known as: Palmitoyl Tripeptide-1, Pal-val-gly-val-ala-pro-gly-oh, BIOPEPTIDE CL, LIPO-GKH, PALMITOYL-GHK TRIPEPTIDE, Palmitoyl Oligopeptide (Retired)
Very thin human evidence
- Regulatory standing. Cosmetic ingredient, not regulated as a drug
- Animal / preclinical only. Evidence is largely animal or in-vitro
- No registered human trials. Nothing registered on ClinicalTrials.gov
- 1 cited source. Includes primary / regulatory sources
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Palmitoyl oligopeptide is a short synthetic peptide attached to palmitic acid, a fatty acid added to help it penetrate the outer layer of skin. It is used as an ingredient in skincare products and is thought to act as a signaling molecule that may encourage skin cells to produce collagen and other structural proteins.
What the evidence shows
It is regulated as a cosmetic ingredient and is not FDA-approved for any medical use, and no registered human clinical trials were found. The published literature is small, about 5 papers, and consists mostly of laboratory and manufacturer-sponsored cosmetic studies, so claims about anti-aging effects in people are not well established.
Key facts
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.
Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.
Cosmetic composition containing an amber extract
Cosmetic composition containing extract of amber as active ingredient plus other active ingredients, e.g. plant extracts or vegetable glycolipid, used e.g. in gels, lotions or creams for skin care
Sources
- PubChem compound record (CID 10231864)
- Registered trials on ClinicalTrials.gov
- Published papers on Europe PMC
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.