A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Palmitoyl tripeptide-1

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Pal-GHK, Matrixyl 3000, Palmitoyl oligopeptide, Pal-val-gly-val-ala-pro-gly-oh, BIOPEPTIDE CL, LIPO-GKH, PALMITOYL-GHK TRIPEPTIDE, Palmitoyl Oligopeptide (Retired)

Evidence score

23/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Cosmetic ingredient, not regulated as a drug
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Palmitoyl tripeptide-1 is a short peptide based on the GHK sequence, with a palmitic acid chain attached to help it penetrate skin. It is used as an ingredient in skincare products, including as one component of the Matrixyl 3000 blend, and is thought to act as a signaling fragment that may encourage skin cells to produce collagen and other matrix proteins.

What the evidence shows

Automatic summaryAnimal / preclinical

It is regulated as a cosmetic ingredient, not a drug, and there are no registered human clinical trials. Published research is sparse, mostly lab work and small manufacturer-linked skin studies, so claims about wrinkle reduction or collagen effects in people are not well established.

Key facts

Molecular formula

C30H54N6O5

Molecular weight

578.8 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

3papers referencing Palmitoyl tripeptide-1

Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism.

J Cosmet Dermatol2026

Permeation behaviour of cosmetic actives into the human stratum corneum.

Int J Pharm2026

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.

Int J Cosmet Sci2026

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.