A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Palmitoyl tripeptide-5

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Syn-Coll, palmitoyl-lysyl-valyl-lysine, SYN-COLL, Pal-Lys-Val-Lys, orb1943203, palmitoyl-L-lysyl-L-valyl-L-lysine, T81562

Evidence score

48/ 100

Emerging evidence

Early evidence, mostly unproven in humans

Regulatory standing. Cosmetic ingredient, not regulated as a drug
Limited human data. Some human data exists, not conclusive
Registered human trials. 2 registered studies on ClinicalTrials.gov, most advanced Phase 4
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Palmitoyl tripeptide-5, sold under the trade name Syn-Coll, is a short synthetic peptide attached to a fatty acid (palmitic acid) to help it penetrate the skin. It is used as an ingredient in topical skincare products and is thought to mimic a sequence of thrombospondin-1, which may activate TGF-beta and signal skin cells to produce more collagen.

What the evidence shows

Automatic summaryLimited human data

Evidence in humans is thin, consisting mainly of manufacturer-linked studies, two registered trials, and about five published papers, so any anti-wrinkle or collagen effects are not firmly established. It is regulated as a cosmetic ingredient and is not FDA-approved for any medical use.

Key facts

Molecular formula

C33H65N5O5

Molecular weight

611.9 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

2registered studies

Phase 4most advanced phase

2completed (sample)

0recruiting (sample)

Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types.

Phase 4CompletedNCT05932732

Pilot Trial to Assess the Performance and Tolerance of mRDX-02-17 Dermal Filler in the Facial Rejuvenation

CompletedNCT03537456

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

5papers referencing Palmitoyl tripeptide-5

Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.

J Cosmet Dermatol2020

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Pharmaceuticals (Basel)2021

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels.

Molecules2023

Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects.

Colloids Surf B Biointerfaces2025

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.