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IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Secretin

FDA approved · Rx

Gastrointestinal hormone peptide

Also known as: ChiRhoStim, Chirhostim, Chirhostim 40, Vitrum, Secretina, Secretine, Secretinum, SECRETIN-FERRING, SecretinKABI, Secretin KABI

Evidence score
95/ 100
Strong evidence

Strong, human-grade evidence

  • Regulatory standing. FDA-approved prescription medicine
  • Human trials. Backed by controlled human studies
  • Registered human trials. 53 registered studies on ClinicalTrials.gov, most advanced Phase 4
  • 2 cited sources. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Secretin is a 27 amino acid peptide hormone naturally released by the small intestine that signals the pancreas to secrete bicarbonate-rich fluid. The synthetic human form, sold as ChiRhoStim, acts on secretin receptors in the pancreas and stomach and is used as a diagnostic agent rather than a treatment.

What the evidence shows

Automatic summaryHuman trials

Synthetic human secretin is FDA approved for stimulating pancreatic secretions to aid in diagnosing pancreatic exocrine dysfunction, for helping diagnose gastrinoma, and for facilitating identification of the pancreatic duct opening during endoscopic procedures. Uses beyond these diagnostic roles, such as the once-popular idea of treating autism, are not supported, and controlled trials in autism did not show benefit.

Key facts

Molecular formula
C130H219N43O42
Molecular weight
3056.4 g/mol
FDA approval
Confirmed on openFDA

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

53registered studies
Phase 4most advanced phase
26completed (sample)
5recruiting (sample)

The Effects of Bariatric Surgeries on Glucose Metabolism

Early Phase 1RecruitingNCT02823665

Secretin Infusion for Pain Due to Chronic Pancreatitis

Phase 2CompletedNCT01265875

The Role of Secretin on the Energy Homeostasis

CompletedNCT04613700

Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor Conspicuity

Early Phase 1WithdrawnNCT01371240

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

7,442papers referencing Secretin

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Proc Natl Acad Sci U S A1998

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

Mol Pharmacol2003

Polypeptide with broad biological activity: isolation from small intestine.

Science1970

Structural diversity of G protein-coupled receptors and significance for drug discovery.

Nat Rev Drug Discov2008

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.