← Library
Sold as a supplement, not an FDA-approved drug. This page is educational information only, not medical advice.
IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Serrapeptase

Supplement

Proteolytic enzyme supplement

Also known as: serratiopeptidase, Serratiopeptidase, Serrapeptase (JAN), Serrapeptasum (INN-Latin), Serrapeptasa (INN-Spanish), Dasen, serrapeptasi, Aniflazime

Evidence score
52/ 100
Moderate evidence

A real evidence base, with gaps

  • Regulatory standing. Sold as a supplement, not an approved drug
  • Limited human data. Some human data exists, not conclusive
  • Registered human trials. 8 registered studies on ClinicalTrials.gov, most advanced Phase 4
  • 1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Serrapeptase, also called serratiopeptidase, is a protein-digesting enzyme originally isolated from Serratia bacteria and sold in the US as a dietary supplement. It is thought to break down proteins involved in inflammation and mucus, though how much of an orally taken enzyme survives digestion and reaches the bloodstream in active form is debated.

What the evidence shows

Automatic summaryLimited human data

It is not FDA approved for any use, and the human evidence is limited to a small number of trials (8 registered) and about 32 published papers, many small or of modest quality, with reviews describing the case for anti-inflammatory or pain benefits as unproven. The listed PubChem formula does not match a large enzyme, so that database entry may be unreliable.

Key facts

Molecular formula
C46H40N8O8
Molecular weight
832.9 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

8registered studies
Phase 4most advanced phase
4completed (sample)
0recruiting (sample)

A Comparison of Recovery After Impacted Wisdom Tooth Removal

Phase 3CompletedNCT07304882

Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery

CompletedNCT07543146

Efficacy and Safety of Hydrogen Inhalation on Bronchiectasis: A Randomized, Multi-center, Double-blind Study

UnknownNCT02765295

The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery

Not Yet RecruitingNCT07269171

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

32papers referencing Serrapeptase

Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.

Int J Oral Maxillofac Surg2008

Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.

Hum Exp Toxicol2013

Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm-related infections.

J Hosp Infect2017

Enzyme-Functionalized Mesoporous Silica Nanoparticles to Target <i>Staphylococcus aureus</i> and Disperse Biofilms.

Int J Nanomedicine2021

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.