Tripeptide-1
Cosmetic ingredientCosmetic signaling tripeptide
Also known as: GHK tripeptide, glycyl-l-histidyl-l-lysine, Prezatide, Liver cell growth factor, Glycyl-histidyl-lysine, Copper(II)ghk, KOLLAREN, PC-1020 FREE BASE, ORISTAR GHK
Early evidence, mostly unproven in humans
- Regulatory standing. Cosmetic ingredient, not regulated as a drug
- Limited human data. Some human data exists, not conclusive
- Registered human trials. 4 registered studies on ClinicalTrials.gov, most advanced Phase 2
- 1 cited source. Includes primary / regulatory sources
Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.
What it is
Tripeptide-1 is a short peptide made of glycine, histidine, and lysine (GHK), a sequence that occurs naturally in human plasma and is also used as an ingredient in skin care products. It is thought to act as a signaling molecule that may influence skin repair processes such as collagen production, and it is best known in its copper-bound form (GHK-Cu).
What the evidence shows
It is not FDA-approved as a drug and is regulated as a cosmetic ingredient. Evidence consists mostly of lab and small cosmetic studies, with only 3 registered human trials (most advanced Phase 2), so effects in humans remain uncertain.
Key facts
Registered human trials
Live from ClinicalTrials.gov, refreshed daily.
Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study
AI-Personalized Skincare Regimen for Facial Photoaging in Women
A Single-Group Study to Evaluate the Effects of an Eyelash Serum on Improving Eyelash Growth
Topical GHK-Cu Gel for Acute Skin Wound Healing
Published literature
Live from Europe PMC. This is how much has been published, not how much is proven in humans.
In vitro development of Ascaris suum from third- to fourth-stage larvae and detection of metabolic antigens in multi-well culture systems.
Soluble complex of complement increases hydraulic conductivity in single microvessels of rat lung.
Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase.
Synthesis, conformation, and activity of HCO-Met-delta Z Leu-Phe-OMe, an active analogue of chemotactic N-formyltripeptides.
Sources
- PubChem compound record (CID 73587)
- Registered trials on ClinicalTrials.gov
- Published papers on Europe PMC
Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.