A cosmetic ingredient, not regulated or approved as a drug. This page is educational information only, not medical advice.

IndexedBuilt automatically from public databases on 2026-09-30. Not yet hand-reviewed by PLOBT.How this works →

Tripeptide-10 citrulline

Cosmetic ingredient

Cosmetic signal peptide

Also known as: Decorinyl, orb1943819, GKPMARPRXONRJX-BWJWTDLKSA-N, T80944

Evidence score

23/ 100

Thin evidence

Very thin human evidence

Regulatory standing. Cosmetic ingredient, not regulated as a drug
Animal / preclinical only. Evidence is largely animal or in-vitro
No registered human trials. Nothing registered on ClinicalTrials.gov
1 cited source. Includes primary / regulatory sources

Computed with the same four public criteria as every profile. The human-evidence grade on an indexed profile is set automatically and may change when it is hand-reviewed. It is not a safety score, not a purity rating, and not medical advice, and not a claim that this compound treats, cures, or prevents any condition.

What it is

Tripeptide-10 citrulline, sold under the trade name Decorinyl, is a short synthetic peptide used as an ingredient in skin care products. It is designed to mimic a fragment of decorin, a protein that helps organize collagen fibers in skin, and is thought to support more regular collagen fibril structure.

What the evidence shows

Automatic summaryAnimal / preclinical

There are no registered human clinical trials and only about two published papers, mostly manufacturer-linked or lab-based, so claims about firmness or wrinkle reduction are not well established in humans. It is regulated as a cosmetic ingredient, not an FDA-approved drug.

Key facts

Molecular formula

C22H42N8O7

Molecular weight

530.6 g/mol

Registered human trials

Live from ClinicalTrials.gov, refreshed daily.

0registered studies

Nonemost advanced phase

0completed (sample)

0recruiting (sample)

Published literature

Live from Europe PMC. This is how much has been published, not how much is proven in humans.

2papers referencing Tripeptide-10 citrulline

A new decorin-like tetrapeptide for optimal organization of collagen fibres.

Int J Cosmet Sci2008

The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study.

J Cosmet Dermatol2017

Sources

Risks, side effects and study doses are only published on hand-reviewed profiles. Want this one reviewed, or spotted something wrong? Tell us.